Apolipoprotein E is a apolipoprotein essential for the metabolism of triglyceride-rich lipoprotein consituents. it has been recognized for its importance in lipoprotein metabolism and cardiovascular disease.
ApoE genotyping may help guide lipid treatment when cardiovascular risks are high. It is used as an adjunct test to aid in the diagnosis of dementia and Alzheimer Disease, but an association has not been confirmed.
Abnormalities in the ApoE gene have been found in neonates with brain injuries and/or defects, and may increase the risk for Cerebral Palsy.
Kuroda MM, Weck ME, Sarwark JF, Hamidulla A, Wainwrigt MS. Association of apolipoprotein E genotype and cerebral palsy in children. Pediatrics 2007;119(2):306-313
The persistent CNS (central nervous system) effect of lead may be more toxic in individuals who have at least one ApoE-Epsilon4 allele. This study suggests that individuals with ApoE polymorphisms may vary in susceptibility to the long-term effects of lead on the central nervous system.
(Stewart WF, Schwartz BS, Simon D, Kelsley K, Todd AC. ApoE genotype, past adult lead exposure, and neurobehavioral function.
Environ Health Perspect. 2002; 110(5): 501-505)
A reduction of ApoE gene type that contains two cysteines decreases detoxification capabilities and the removal of mercury and other thiol-reactive toxicants. (Haley B., The relationship of the toxic effects of mercury to exacerbation of the medical condition classified as Alzheimer's disease.
Medical Veritas 4 (2007); 1484-1498)